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Figure 5


Fig. 5. Skeletal muscle from Myogflox/flox and Myogflox{Delta}/flox{Delta} mice at 10 weeks of age. (A-D) Cross-sections (A,B) and longitudinal sections (C,D) of hindlimbs. (E,F) Sections through tongues. (G-J) Sections through diaphragms. One Myogflox{Delta}/flox{Delta} mouse has a thin diaphragm (H). Thin diaphragms were found in only a single pair of mice from a single litter. All other Myogflox{Delta}/flox{Delta} mice had normal diaphragms (J). Scale bar: 100 µm. (K) Identical myofiber diameters were observed in Myogflox/flox and Myogflox{Delta}/flox{Delta} mice. Myofiber diameters were determined from cross-sections of hindlimbs of mice at 10 weeks of age. Each column represents the diameters determined for individual myofibers from a single hindlimb section (squares). The genotypes are shown below the graph.





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