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Figure 5


Fig. 5. Regulation of germ cell cycle during dauer development. Under reduced daf-2/insulin-like receptor and/or daf-7/TGF-ß activity, daf-18/PTEN, par-4/LKB1 and aak-1,aak-2/AMPK mediate the downregulation of germline proliferation during dauer development. Although the role of par-4 in aak-1 activity is obvious, the relationship between daf-18, par-4 and aak-2 remains unclear. Arrows and bars represent positive and negative genetic interactions, respectively.





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