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Fig. 7. A proposed model of URI-1 function. Genetic and cell biological
analysis show that URI-1 prevents DNA damage and the subsequent activation of
the DNA damage signaling pathway by functioning directly or indirectly in DNA
damaging processes and/or DNA repair processes. DNA damage caused by
deficiency of URI-1 affects germ cells by leading to proliferation arrest in
the mitotic region and p53-dependent apoptosis, as well as cell cycle arrest
in the meiotic part of the germline. This phenotypes are consistent with
reported read outs of the DNA-damage response
(Deng et al., 2004;
Stergiou and Hengartner,
2004).
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