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Figure 4


Fig. 4. P2-receptor antagonists reduce the cytosolic Ca2+ elevations. Inhibitors (100 µM each) were applied 8 minutes prior to agonist application. The P2Y1-receptor-specific antagonist MRS2179 reduced the Ca2+ signal evoked by ATP or ADP (50 µM each). The non-selective P2-receptor antagonists suramin or PPADS reduced the Ca2+ signals evoked by either ATP, ADP or UTP (mean±s.d., n=5-8, *P<0.05, **P<0.01).





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