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Figure 7


Fig. 7. Inhibition of Ena/VASP leads to disruption of the FN matrix. (A-D) Stacked z-series of FN staining reveals a fragmentation of the matrix (arrowheads), separation of somites from overlying ectoderm (arrows), gaps in the intersomitic FN matrix (asterisks) and loss of defined boundaries between the somite and neural tube or notochord in FP4-mito (bracket) (A), but not AP4-mito (C) injected embryos. Injected side is on the right. High magnification images of the boundary between the dorsal somite and neural tube reveals a disruption in the integrity of the FN matrix in FP4-mito (B) but not AP4-mito (D) injected embryos. (E-G) Stacked z-series show a dense FN matrix (white) on the interior BCR surface of an uninjected embryo (green, E) and an embryo injected with AP4-mito (green, F). By contrast, expression of FP4-mito (G) blocks FN matrix assembly as revealed by a thin or absent FN matrix in areas of GFP signal. s, somite; nt, neural tube. Scale bars: 100 µm.





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