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Figure 7


Fig. 7. Pathfinding of olfactory bulb axons in the telencephalon of Dcc mutant embryo. (A-D) Projection of olfactory bulb axons in E14.5 heterozygous (A,C) and homozygous (B,D) Dcc mutant embryos visualized with anti-neuropilin 1 antibody. The number of axons elongating from the ventral side of the olfactory bulb in the homozygous mutant (arrow in D) is much lower than that in the heterozygous mutant. The phenotype was apparent in all of the 20 homozygous mutant telencephalons. Left, rostral aspect; top, dorsal aspect. (E-H) Fluorescent dye labeling of medial olfactory bulb axons in E16.5 heterozygous (E,G) and homozygous (F,H) Dcc mutant embryos. (E,F) Lateral views of left hemispheres. Left, rostral aspect; top, dorsal aspect. (G,H) Ventral views of left hemispheres showing the dye-labeled ventral pathways; left, rostral aspect; top, lateral aspect. Dye-labeled axons split into the dorsal (white arrowheads in E,F) and ventral (arrows in E-H) pathways to enter into the LOT. In the homozygous telencephalon, axons projecting in the ventral pathway are tangled and misdirected back to the olfactory bulb. This aberrant projection of olfactory bulb axons was detected in all of 15 homozygous Dcc mutants and three out of five homozygous netrin 1 mutants. Scale bars: 1 mm in A,B; 500 µm in C-H.





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