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Fig. 3. Model predicts experimental patterning results. (A) A cross
section of a stage 20-24 chick embryo indicates expression of nkx2.2
(red) and cells transfected with a signaling-defective Ptc (green) [adapted,
with permission, from Briscoe et al.
(Briscoe et al., 2001)].
(B) Modeling results of the Gli1 concentration in both the wild-type
and transfected sides of the embryo after 63 hours of Shh secretion match
experimental profiles. The dashed line indicates the experimentally measured
Nkx2.2 profile at stage 18, t=
50 hours
(Ericson et al., 1997b). See
text for relationship between Nkx2.2 and Gli1. Simulation initial conditions
and parameters are the same as those listed in
Fig. 2, except within the
transfected regions where (Kptc
KGli3)
106. See text for details.
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