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Fig. 6. Shh aggregation by Dispatched can overcome diffusion limitations.
The Gli1 protein interface position at t=83 hours is shown at various
levels of (A) initial Dispatched intracellular concentration and
(B) diffusivity of a Shh aggregate. Simulation initial conditions and
parameters are the same as those listed in
Fig. 2; however, Dispatched
mechanism parameters and equations were added (see Fig. S4 in the
supplementary material).
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