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Fig. 2. Sequence analysis of hydkk1/2/4. (A)
TCoffee alignment of HyDkk1/2/4 with the CRD2 of available Dkk molecules (see
Materials and methods). (B) Domain structure of mouse Dkk4, NvDkk1/2/4
and HyDkk1/2/4; shaded boxes indicate conserved residues within CRD2;
cysteines in red. (C) IQPNNI ML tree of Dkk CRD2 domains with
TREE-PUZZLE support values (>50).