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Figure 1


Fig. 1. The organization of the DAAM locus and the isolation of DAAM mutations. (A) The 1F2-3 cytological region includes the predicted gene CG14622 that we named DAAM. Position of two P-element insertion are shown, EP(1)1336 and EP(1)1542, which have been used to generate DAAM loss-of-function alleles including large 5' deficiencies. The full-length cDNA clone RE67944 consists of 12 exons, translation starts in exon 4. (B) The full-length DAAM cDNA clone carries a 1165 bp 5' UTR and a 731 bp 3' UTR, and encodes a predicted protein of 1153 amino acids, which contains several homology domains, including GBD (GTPase binding domain), DID (Diaphanous inhibitory domain), DD (dimerization domain), CC (coiled-coil region), FH1 (formin homology domain 1), FH2 (formin homology domain 2) and DAD (Diaphanous autoinhibitory domain). The activated form of DAAM (C-DAAM) includes the C-terminal 637 amino acids of the protein. The position of the 3' deficiency alleles is shown at the bottom.





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