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Fig. 2. Localization of endogenous and MCK-B2 transgene-derived laminin
ß2. (A,B) In control skeletal muscle, endogenous mouse laminin
ß2 (A) is concentrated at synapses (arrows) doubly labeled by
-bungarotoxin (B); ß2 is also found in extrasynaptic regions of
muscle fibers (A). (C,D) In MCK-B2 transgenics, antibody specific for
transgene-derived rat ß2 (C) labels only synapses in skeletal muscle
(arrows), identified by -bungarotoxin (D). (E-H)
Transgene-derived rat laminin ß2 is also found in cardiac muscle BMs (E),
in circular (cm) but not longitudinal (lm) smooth muscle or crypt (c)
epithelial BMs of intestine (G), and weakly in large airway smooth muscle of
lung (arrow in H) but not in alveolar (alv) BMs. No rat ß2 was detected
in glomeruli (g) in kidney (F). Scale bars: 25 µm in A-D; 100 µm in E,H;
50 µm in F,G.
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