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Figure 5


Fig. 5. Restoration of proper synaptic architecture and BM composition in skeletal muscle from Lamb2-/-; MCK-B2 mice. (A,B) Colocalization of rat laminin ß2 (A) with {alpha}-bungarotoxin (B) in a highly ramified skeletal muscle synapse. (C,D) Restoration of laminin {alpha}5 to synaptic BMs (C) identified by {alpha}-bungarotoxin (D). (E,F) Laminin ß1 (E, green in F) is not associated with the {alpha}-bungarotoxin-positive synaptic clefts (red in the merged image in F). Scale bar: 20 µm for A-F.





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