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Fig. 5. Craniofacial phenotype of Tbx1 mutants at E17.5, shown by
transverse histological sections, and bone and cartilage staining.
(A) Wild-type embryo. (B) The conditional mutant embryos at
E17.5 are edematous and lack the pinna (p). (C,D) Histological analysis
of the mutant (D) compared with wild-type offspring (C) reveals the presence
of cleft palate in the mutants (D, star). (E-H) Bone and cartilage
staining of E17.5 wild-type (E,G) and mutant (F,H) embryos. The mutant (F) has
cleft palate (arrow), aplasia of the tympanic rings (arrowhead in E), and
fused basisphenoid and basioccipital bones (asterisks). EC, ear capsule;
PEKO/-, Tbx1 flox/null; Foxg1-Cre/+; WT, wild type; ZA, zygomatic
arches. Scale bars: 0.8 mm in B; 300 µm in D; 0.5 mm in F,H.
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