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Figure 7


Fig. 7. Thymus, thyroid and cardiovascular phenotype of Tbx1 conditional mutants shown by transverse histological sections. (A) An E17.5 wild-type embryo with the thymus gland (tm) and the location of the right subclavian artery (arrow) indicated. (B) A homozygous conditional null embryo of the same stage shows thymus aplasia (asterisks), as well as the presence of a retroesophageal right subclavian artery (RSA, arrow). (C,D) The thyroid glands (th) of wild-type (C) and mutant (D) embryos at E17.5. (E) Wild-type embryo shows normal separation of the aortic (a) and pulmonary (p) trunks. (F) Abnormal septation of the outflow tract results in persistent truncus arteriosus (PTA) in the mutant of the same stage. (G-I) Sections through the heart show a ventricular septal defect (VSD) in a Tbx1 homozygous conditional mutant (H) and a Tbx1-/- embryo (I), compared with a wild-type litter mate (G). (J-M) Transverse sections at E10.5 show normal development of atria (A) and ventricles (V), as well as the outflow tract in both wild-type (J,L) and conditional mutant (K,M) embryos. WT, wild type; PEKO/-, Tbx1 flox/null; Foxg1-Cre/+; -/-, Tbx1-/-. Scale bars: 300 µm in B,D,F; 100 µm in G-I; 50 µm in K,M.





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