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Fig. 4. Wingless signalling opposes Hedgehog signalling in the regulation of
Lethal of scute. (A) In wild-type embryos, Lethal of scute (L'sc,
black) is expressed in about six midline cells (arrows) in each segment.
(B) In wingless mutants, the number of Lethal of scute cells
in a cluster (arrows) increases, up to 10 cells per segment. By contrast, in
hedgehog mutants, Lethal of scute expression is lost (see
Fig. 3B). (C) Cells
taken from donors that express Wingless ubiquitously (V2H-GAL4/+;
UAS-wg/+) were transplanted next to the midline of wild-type embryos.
Wingless-expressing cells (asterisk) repress Lethal of scute (dark purple) in
the segment into which they integrate (arrowhead), whereas the expression of
Lethal of scute in adjacent segments is not affected (arrows). The expression
of Gooseberry-Distal (Gsb-d, brown), which serves as a segmental marker, does
not change. All embryos are at stage 10. Ventral views, anterior to the left;
brackets outline the midline.
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