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Fig. 1. Ectopic expression of Hox genes and other defects in
sor-1 loss-of-function mutants. (A) Expression
of egl-5 in a wild-type L2 larva. The expression of egl-5 is
restricted to the tail (not shown) and is absent in the head (bracket).
(B) Ectopic expression of egl-5 in a sor-1 mutant.
egl-5 is ectopically expressed in many head neurons (marked with
bar). (C) Expression of mab-5 in a wild-type larva. The
expression of mab-5 is confined to the posterior region (arrow).
(D) Ectopic expression of mab-5 in a sor-1 mutant.
mab-5 is expressed in the head neurons and hypodermal cells. The
expression of mab-5::gfp is absent from the tail region (arrow).
(E) Normal expression of pkd-2::gfp in all nine pairs of
B-type ray neurons (arrow) and in four head neurons (arrowhead) in a wild-type
male. PKD-2::GFP marks both the cell body and the axon of neurons. (F)
Ectopic expression of pkd-2::gfp in a sor-1(RNAi) male,
indicating that ectopic rays are generated in the anterior body region. Five
ectopic rays are located between the arrows. (G) sor-1 mutant
hermaphrodites have a protruding vulva phenotype (arrow). (H) Partial
hermaphrodite-to-male sexual transformation. An ectopic male ray (arrow), as
visualized with pkd-2::gfp, is generated in a sor-1
hermaphrodite. This animal also contains a pkd-2::gfp-positive neuron
in the head (arrowhead), which is normally expressed in four male-specific
head neurons.
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