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Fig. 6. Lack of orthologs of SOR-1 and SOP-2 in C. briggsae.
(A) Schematic representation of sor-1 and its neighboring
genes in C. elegans and in C. briggsae. ZK1236.4 corresponds
to a transposon in the genome. CBG18140 does not have a clear homolog in
C. elegans. Although sor-1 (ZK1236.3) shows some similarity
with CBG18142, the latter does not appear to be the ortholog of sor-1
(see Results). (B) Schematic representation of sop-2 and its
neighboring genes in C. elegans and in C. briggsae. CBG20941
does not have a clear homolog in C. elegans. sre-52 and
sre-54 encode a class of 7 TM chemoreceptors (sre family).
(C) Model for the putative SOP-2/SOR-1 complex-mediated transcriptional
repression. SOR-1, SOP-2 and perhaps other unidentified components form an
RNA-binding complex, which may further recruit chromatin remodeling activity.
The RNA components could be involved in targeting the SOP-2/SOR-1 complex to
target loci and/or maintaining the integrity of the complex and the distinct
nuclear bodies formed by SOR-1 and SOP-2.
