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Figure 3


Fig. 3. Epiblast defects in type I mutants. (A-L) All conceptuses on the left of each image are either wild type or heterozygous for the Ets2 mutation, and those on the right are either type I or type II homozygous mutant littermates, showing the expression profile (either single- or double-probe in situ hybridization) of the indicated gene transcripts. All are sagittal views and, where applicable, posterior is to the right. The morphologically identifiable embryonic-extraembryonic junction is denoted by arrowheads. (A,C,F,G,I) E6.75 control conceptuses and their type I mutant littermates, with the exception of I, where a type II mutant is also included. (H) E6.75 control conceptuses and their type II mutant littermates. (B,D,E,K) E7.75 control conceptuses and their type I mutant littermates. (J,L) E8.5 control conceptuses and their type I mutant littermates. Scale bars: 100 µm. All images without scale bars have the same magnification as A.





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