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Fig. 4. VE defects in type-I mutants. (A-M) Sagittal views, posterior
to the right. The morphologically identifiable embryonic-extraembryonic
junction is denoted by arrowheads and the VE area below each arrow denotes the
VE of the distal tip. Dashed lines represent the DVE/AVE region and asterisks
the definitive endoderm. (A-F) Wild-type conceptuses at the stages indicated
showing either the Hex or cerberus expression profile. (G,H,J,K,L)
All conceptuses on the left of each image are either E6.75 wild type or
heterozygous for the Ets2 mutation, and those on the right are either
type I and/or type II homozygous mutant littermates, showing the expression
profile (either single- or double-probe in situ hybridization) of the
indicated gene transcripts. The image on the right in H is a sagittal section
of the image to its left. (I) E7.75 type I mutant (left) and its sagittal
section (right), showing expression of Hex. (M) E7.75 control
conceptus (left) and its type I mutant littermate (right), showing expression
of Otx2. Scale bars: 100 µm; in A for A-D; in E for E-H,J,K.
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