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Figure 5


Fig. 5. Type I defects in chimeras generated with 2N ES+/+ cells and 4N Ets2db1/Ets2db1 embryos. All images on the left are bright-field (BF) and GFP views of E7.75 chimeras generated by aggregations of GFP-positive 2N ES+/+ cells with 4N Ets2db1/Ets2db1, 4N Ets2db1/Ets2+ or 4N Ets2+/Ets2+ embryos. All images to the right are whole-mount in situ hybridizations of the conceptuses to their left, showing the expression profile of the genes indicated. (A) 2N ES+/+{leftrightarrow}4N Ets2db1/Ets2+ E7.75 chimera showing normal development that is indistinguishable from its 2N ES+/+{leftrightarrow}4N Ets2+/Ets2+ counterpart (data not shown). (B-D) 2N ES+/+{leftrightarrow}4N Ets2db1/Ets2db1 E7.75 chimeras showing abnormal development with defects identical to those seen in E7.75 type I mutants, as judged morphologically and by T, Hex and Oct4 expression. Scale bars: 100 µm.





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