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Fig. 5. The zinc transport activity of FOI is required for proper gonad
morphogenesis in vivo. Graph represents a comparison of the amount of FOI
function exhibited by each mutant version of FOI, relative to the activity of
wild-type HA-FOI. Data include zinc transport activity, as assayed by zinc
uptake in cultured cells [blue, data from Mathews et al.
(Mathews et al., 2005)], and
in vivo rescue activity, as judged by gonad compaction (red), germ cell
ensheathment (gray) and DE-cadherin expression (green) (data from Figs
2,
3,
4 but normalized to HA-FOI
controls). The zinc transport ability of each FOI protein directly correlates
with its ability to rescue the foi gonad phenotype in vivo.
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