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Fig. 6. C/EBP
influences maturation of the capillary-epithelial
interface. Lung sections from Cebpa
/
mice and control littermates were obtained at E18.5 and immunostained for vWF
and -SMA. In controls (A), an extensive vascular network was
observed in which vessels are located in close apposition to squamous type I
cells. In Cebpa/ mice (B), a
relatively undeveloped capillary bed, with vessels embedded within the
thickened mesenchyme of the immature lung saccules, was observed. Expression
of -SMA was detected in smooth muscle cells surrounding the bronchioles
in both control (C) and Cebpa/
(D) mice. Scale bar: 50 µm.
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