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Figure 9


Fig. 9. Decreased expression of C/EBP{alpha} in Titf1–/– mice and Foxa2{Delta}/{Delta} mice. Lung sections from Titf1+/–, Titf1–/–, Foxa2flx/flx and Foxa2{Delta}/{Delta} mice were prepared on E18.5 and immunostained for C/EBP{alpha}. C/EBP{alpha} was not altered in lungs from Titf1+/– (A) and Foxa2flx/flx (C) mice. Titf1–/– mice (B) have a rudimentary bronchial tree associated with absent peripheral lung formation in which C/EBP{alpha} staining was markedly decreased or absent. Expression of C/EBP{alpha} was decreased in respiratory epithelial cells in the lungs of Foxa2{Delta}/{Delta} (deficient) mice (D). Scale bar: 25 µm.





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