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Figure 3


Fig. 3. ICF mutations result in a partial loss of function of Dnmt3b. (A) Progeny derived from intercrosses of Dnmt3b mutants. (B-D) DNA methylation analysis of Dnmt3b mutant mice. Genomic DNA from E12.5 embryos (B), tails of adult mice (C) and various tissues of newborns (D) was digested with HpaII or MaeII (left panel of B) and hybridized to probes for major satellite repeats (left panel of B), minor satellite repeats (middle panel of B;C,D), and endogenous C-type retrovirus repeats (pMO; right panel of B). DNA digested with MspI (M) was used as a control for a complete lack of DNA methylation.





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