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Fig. 4. Developmental defects of Dnmt3b-/- embryos.
(A) Analysis of embryos derived from intercrosses of
Dnmt3b+/- mice. Numbers in parentheses indicate the number
of abnormal embryos. (B) Gross morphology of
Dnmt3b-/- embryos and a wild-type littermate at 13.5 dpc.
Some Dnmt3b-/- embryos showed a smaller and paler fetal
liver than their wild-type littermates, which could be recognized from outside
(middle embryo, arrow). Some Dnmt3b-/- embryos showed
bleeding at the head region (right embryo, arrow). (C) Posterior view
of the Dnmt3b-/- embryo shown in B. Most of the
Dnmt3b-/- embryo showed subcutaneous edema (arrows) at
13.5 dpc. (D) Ventricular septum defect in the heart of a
Dnmt3b-/- embryo at 14.5 dpc. The right panel shows a
higher magnification of the inset shown in D. (E) Ectopic hemorrhage at
the dorsal root ganglion of a Dnmt3b-/- embryo at 12.5
dpc. (F) Malformation of the fetal liver in
Dnmt3b-/- embryos at 13.5 dpc.
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