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Fig. 5. Gross appearance of ICF mice. (A) Gross morphology of
wild-type (+/+), T/T and T/+ newborns. The T/T pup was smaller than its
wild-type and heterozygous littermates, and lacked a milk spot. (B)
Average body weight of +/+ (n=6), T/+ (n=5), G/+
(n=7) and T/G (n=5) littermates at birth. Error bars
represent the standard error. (C) Growth curves of ICF mutant mice
(circle) and control mice (black square). Three to 10 mice of each genotype
were used for each data point, except for 15-week-old mutant mice of which we
analyzed only two. Error bars represent the standard errors. (D) Gross
appearance of the face of a T/T mouse and a T/+ littermate at P60. (E)
Dorsal view of bone staining of an adult T/T skull (left) and a T/+ littermate
skull (right). The length of the lines of 
, ß, 
and 
indicated in the panel is shown below. (F) Dorsal (upper) and lateral
(lower) views of bone staining of a newborn G/- (left) and a G/+ (right)
skull. The lines demonstrate the foremen.
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