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Fig. 2. Loss of Ph accounts for l(X)MB342 mutant phenotypes.
(A) l(X)MB342 carries a lethal mutation within the internal
2D3 to 2E1, defined by the distal breaking points of Df(1)64c18 and
Df(1)Pgd-kz. All rescuing regions of duplication are shown in green,
while the l(X)MB342-complemented (purple) and
l(X)MB342-non-complemented (red) deleted segments are shown. In
addition, three (in red) out of five lethal complementation groups around this
region failed to complement with l(X)MB342. (B) Composite
confocal images of a mosaic adult brain containing MARCM clones of
ph602 homozygous mutant neurons. Phenotypes are similar to
l(X)MB342 mutant clones shown in
Fig. 1D. (C) Composite
confocal images of a mosaic adult brain containing
P{ph-d+}-rescued l(X)MB342 mutant
neuronal clones. Genotypes: (B)
FRT19A,ph602/FRT19A,hs-FLP,tubP-GAL80;UAS-mCD8-GFP/+;GAL4-OK107/+;
and (C)
FRT19A,l(X)MB342/FRT19A,hs-FLP,tubP-GAL80;UAS-mCD8-GFP/+;P{ph-d+}/+;GAL4-OK107/+.
Scale bar: 20 µm.
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