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Figure 6


Fig. 6. Disruption of laminin and integrin genes results in EMEs that can be suppressed by clr-1 mutants. (A-H) All images correspond to the boxed area in Fig. 1A. Red arrows indicate individual EMEs and green arrows indicate intact lateral BWM membranes. EMEs are seen in trIs10 worms fed lam-1(RNAi) (A), lam-2(RNAi) (B), epi-1(RNAi) (C) or pat-2(RNAi) (D). (E-H) The EME phenotype is strongly suppressed for each genotype in the background of clr-1(e1745) at 20°C. (I-K) A dorsal right-hand side view of adult worms in the background of trIs30, showing BWMs numbers 9, 11, 13 (green arrowhead) and 15, right to left, according to our numbering scheme (Dixon and Roy, 2005), extending muscle arms (red arrowheads) to the dorsal nerve cord (blue arrowheads). A MAD phenotype is seen in lam-1(rh219); trIs30 (I), pat-2(RNAi); trIs30 (J) and unc-52(e998); trIs30 (K) worms. Scale bar: in A, 50 µm for A-H; 50 µm in I-K.





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