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Figure 1


Fig. 1. Loss of Jag1 antibody staining in the inner ear of Jag1 conditional knockout mice. (A,B) Confocal images of sagittal cryosections at E10.5 (dorsal to the left). (A) Littermate control. The Jag1 antibody stains a patch of cells (arrow) in the ventral part of the otocyst. (B) Jag1 conditional knockout. The patch of Jag1 staining is lost. (C,D) Confocal optical sections of apices of whole-mount E17.5 cochleas. (C) Littermate control. Jag1 is detected in a narrow band of cells (arrow) - the future sensory patch. (D) Jag1 conditional knockout. The Jag1 staining is lost.





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