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Figure 2


Fig. 2. Defective sensory patch development in the Jag1 conditional knockout cochlea. Confocal images of whole-mount E17.5 cochleas stained with fluorescent phalloidin. (A) In the apex of the control cochlea, faint lines of actin staining prefigure the appearance of the inner hair cells (arrow); no hint of outer hair cells is yet visible. (B) In the Jag1 conditional knockout littermate, the appearance of the cochlear apex is similar, with no sign of premature differentiation. (C) In the middle part of the control cochlea, the standard pattern of one row of inner hair cells (IHCs) and three rows of outer hair cells (OHCs) is seen. (D) In the middle part of the Jag1 conditional knockout cochlea, approximately two disorganized rows of hair cells are produced. (E) In the mid-basal region of the Jag1 conditional knockout cochlea, hair cells lie in islands (arrows) separated by gaps of bare epithelium; the mid-basal region of the control cochlea (not shown) has the same pattern of four rows of hair cells as in the middle region (C).





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