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Figure 4


Fig. 4. The vestibular apparatus is defective in the Jag1 conditional knockout. Specimens at E17.5. (A,B) Freshly dissected inner ears under the dissecting microscope; medial view, anterior towards the left. The Jag1 conditional knockout (B) has a truncated anterior semicircular canal (left, asterisk) and a missing posterior semicircular canal (right, asterisk). (C,D) Confocal optical sections through the horizontal crista and utricular macula, stained for actin and DNA. In the wild-type control (C), nuclei of hair cells and supporting cells are arranged in two distinct layers (arrows in C and C'); in the Jag1 conditional knockout (D), the corresponding patches are smaller and there is only one layer of nuclei, reflecting absence of hair cells. (C',D') Enlargements of the horizontal crista. (E,F) Confocal optical sections of the saccular macula, stained for actin, DNA and calretinin. The mutant macula appears to be unaffected by loss of Jag1.





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