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Fig. 1. Comparison of sequence of zebrafish ß-catenin-2 with other
ß-catenins. (A) ClustalW-generated sequence alignment of the
least conserved regions of Xenopus ß-catenin (Accession Number
AAA49670), goldfish ß-catenin (AAP94282.1), zebrafish ß-catenin-1
(AAC59732.1), zebrafish ß-catenin-2 (AAM53438.1), and computationally
predicted ß-catenin-1 and ß-catenin-2 proteins from Fugu
and Tetraodon (using Ensembl genomic data sets). Of the 55 amino acid
differences between the two zebrafish ß-catenins, five changes are at
positions 105-109 and 28 are in the N-terminal end of the protein (the same
region that shows high levels of divergence in the predicted pufferfish
ß-catenin-2 proteins). Based on sequences in these two regions, zebrafish
ß-catenin-1 clearly forms a closely related group with the
Xenopus and goldfish ß-catenins, and with pufferfish
ß-catenin-1, whereas zebrafish and pufferfish ß-catenin-2 are more
distantly related. (B) Maximum parsimony analysis of vertebrate and
Ciona ß-catenin cDNA nucleotide coding sequences. Numbers indicate the
hits supporting the branching pattern from 1000 bootstraps.
