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Fig. 7. Mutation of Unc5c results in the disorganization of the dorsal funiculus. Cytoarchitecture and axonal patterning of the E12.5 Dcc mutant and Unc5c^rcm mutant dorsal spinal cord revealed by double staining with Nissl method and neurofilament immunohistochemistry (A,B), and by immunohistochemistry for TrkA (C,E) and TrkC (D,F). (A,C,D) Dcc mutant mice. (B,E,F) Unc5c^rcm mutant mice. (A) The dorsal funiculus is normally formed in Dcc mutant mice with a sharp inner border (arrowheads). (B) The Unc5c^rcm mutant dorsal spinal cord contains an ectopic cell island in the marginal zone (arrow), and neurofilament-positive axons form a triangle dorsal funiculus with an irregular inner border at the ventral part of the dorsal funiculus. Insets indicate higher magnification of the dorsal funiculus. (C,D) Both TrkA- and TrkC-positive afferents grow into the marginal zone without invading the dorsal gray matter, both of which show a sharp inner border (arrowheads). (E,F) TrkA- and TrkC-positive axons in Unc5c^rcm mutant mice form an aberrant dorsal funiculus, slightly spreading into the dorsal gray matter (arrows). The medial region of the dorsal funiculus has a sharp border to the dorsal mantle layer (arrowheads in F). Scale bar: 100 µm.

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