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Figure 2


Fig. 2. Par3{Delta}E3/{Delta}E3 embryos show growth retardation at E9.5 and cardiac defect at E10.5. (A-G) Gross appearance of wild-type (A,D,F) and Par3{Delta}E3/{Delta}E3 (B,C,E,G) embryos at E9.5 (A-C) and E10.5 (D-G; enlarged, D'-G'). Mild (B) to severe (C) growth retardation is observed in Par3{Delta}E3/{Delta}E3 embryos at E9.5. Although the common ventricular chamber (asterisk) and the common atrial chamber (arrowhead) are formed in Par3{Delta}E3/{Delta}E3 embryo at E10.5 (E'), the heart is hypoplastic. A severely affected Par3{Delta}E3/{Delta}E3 embryo at E10.5 (G,G') shows an enlarged atrium (arrow) and peripheral edema (arrowheads). Scale bars: 0.5 mm. (H,I) Histological analysis of the placentas from wild-type (H) and Par3{Delta}E3/{Delta}E3 (I) littermates at E10.5 shows no significant difference in the development of the giant cells (gc), spongiotrophoblasts (sp), labyrinth (la) and cholionic plates (cp). Both placentas show abundant embryonic blood vessels (arrows) and their close proximity to maternal blood sinuses (arrowheads). The indicated regions are enlarged in H' and I'. Scale bars: 200 µm.





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