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Fig. 7. In situ hybridization analysis of Wnt1, Otx2 and
T. The expression of these markers was relatively unaffected in
Mll–/– embryos (B,D-F). Expression of
Wnt1 in wild-type E9.5 embryo (A) compared with
Mll–/– E10.5 (B). Buckling of the
neural tube is caused by the loss of somites. Expression of Otx2 in
wild-type E9.5 embryo (C) compared with
Mll–/– E10.5 embryo (D). Expression of
brachyury (T) in Mll–/– embryos at
E8.5 (E) and E9.5 (F) shows that it was correctly established
and maintained.
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