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Fig. 7. Defects in the rostral migratory stream (RMS) in Fez-deficient
mice. (A,B) Neurons born at E14.5 in control (WT) and
Fez-deficient (Fez–/–) embryos were
labeled with BrdU and their positions were determined at E18.5; coronal
sections, medial to the right. The total number of BrdU-positive neurons in
Fez-deficient embryos was slightly reduced, and they were not
localized to the glomerular layer but were located mainly on the medial side
of the granule cell layer. (C-F) Expression of Dlx1 at E18.5
(C,D) and E15.5 (E,F); sagittal sections, with anterior to the right.
Dlx1 is expressed in interneuron progenitors of the OB and marks the
rostral migratory stream (RMS, arrows). The RMS from the ganglionic eminence
to the olfactory bulb was shorter in Fez-deficient embryos than in
wild type at E15.5 and E18.5. The distribution of Dlx1-expressing
cells was affected in the Fez–/– olfactory
bulb (arrowheads, C,D). (G,H) The expression of Slit1
in the septum and ganglionic eminence was not significantly affected in
Fez-deficient embryos (H), compared with wild type (G).
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