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Figure 9


Fig. 9. An eve->grn->zfh1 genetic cascade specifies aCC motor axon identity. Within the VNC, GMC1-1a is one of the first GMCs to divide and produces two postmitotic neurons: the aCC pioneer motoneuron and its sibling the pCC interneuron. In aCC and pCC, eve expression is independent of the activity of Notch signaling, whereas grn and zfh1 are suppressed by Notch signaling, and vnd is activated by Notch. The GMC4-2a divides later and produces the RP2 motoneuron and the RP2sib. In contrast to aCC/pCC, in the RP2 neuron, eve, grn and zfh1 do not regulate each other and in addition expression of all three genes is dependant upon Notch signaling. Although pros function is essential for proper GMC1-1a fate, GMC4-2a specification is under control of concerted activities of pros, hkb, ftz and pdm1. The orange boxes indicate genes regulated and/or sensitive to Notch signaling.





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