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Fig. 2. FGF9 induces mesenchymal and epithelial expansion in vivo. (A-D) Bi-transgenic TRE-Fgf9-IRES-eGfp;SPC-rtTA lungs from E11.5 and E12.5 embryos induced for 48 hours with doxycycline (Fgf9^dox(48)) (B,D) exhibit increased overall size, an extended mesenchymal area and a reduction in branching compared with controls (A,C). (E,F) eGFP fluorescence in control (E) and Fgf9^dox(48) (F) lung epithelium. (G,H) E14.5, Fgf9^dox(48) lungs (H) demonstrated an increased size and expanded epithelial lumens. (I,J) Whole-mount in situ hybridization demonstrates Fgf9 epithelial expression in E14.5 Fgf9^dox(48) lungs (J), consistent with eGFP fluorescence (F). Fgf9 expression and eGFP fluorescence was not seen in single TRE-Fgf9-IRES-eGfp lungs (E,I). G-J are left lung lobes.

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