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Figure 4


Fig. 4. FGF9 positively regulates HH signaling. (A,B) Whole-mount in situ hybridization demonstrates reduced Shh expression in E11.5 Fgf9–/– distal lung epithelium (box, B) compared with controls (A). Attached esophagus (e), by contrast, retained a similar level of expression in Fgf9–/– and wild-type controls. (C,D) Ptch1 expression was downregulated in E11.5 Fgf9–/– distal sub-epithelial mesenchyme (D). Esophageal expression of Ptch1, however, was not changed. (E-H) Increased Shh and sub-epithelial Ptch1 expression both distally and proximally in E11.5 Fgf9dox(48) lungs (F,H), compared with the distally restricted expression in controls (E,G). (I-P) FGF9 regulation of Shh and SHH signaling (Ptch1 expression) at E12.5 is similar to E11.5 (A-H). I-L are left lobes.





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