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Figure 2


Fig. 2. Tak1{Delta}/{Delta} embryos are abnormal by E9.5. (A-C) E9.5 embryos. (D-F) E10.5 embryos. (A,D) Tak1+/{Delta} control embryos. (B,C,E,F) Tak1{Delta}/{Delta} embryos. The Class II Tak1{Delta}/{Delta} embryo at E9.5 (B) is slightly reduced in size. The Class I Tak1{Delta}/{Delta} embryo (C) is further reduced in size in comparison with the embryo in B, and has a pericardial edema (arrow). The less severely affected Tak1{Delta}/{Delta} embryo at E10.5 (E) is reduced in size and has a small head. The more severely affected Tak1{Delta}/{Delta} embryo at E10.5 (F) is severely reduced in size, and has localized areas of necrosis and a large pericardial edema (arrow).





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