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Fig. 1. Localisation of p63 mRNA in frontal sections of embryonic mouse
heads and in developing skin. (A) Prior to morphological tooth
formation (E10), p63 transcripts were seen throughout the simple
epithelium. (B-D) During the initiation (E11), placode (E12) and cap
(E15) stages, p63 expression continued in all oral and dental
epithelia. (E) At the bell stage, p63 expression was
particularly intense in the outer enamel epithelium and weaker in the inner
enamel epithelium. (F) At E14, transcripts were intense in the
epithelium of palatal shelves. (G) p63 transcripts were
present in simple surface ectoderm at E11. (H) At E15, p63
expression continued in the basal epithelial cell layer, whereas it was
downregulated in the most superficial cells. Dashed line indicates the
epidermal surface. (I) At E17, p63 expression continued in the
basal epithelial cells and it was intense in the stage 1-4 hair follicles.
iee, inner enamel epithelium; ns, nasal septum; oee, outer enamel epithelium;
ps, palatal shelf. Scale bar: 200 µm.
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