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Fig. 3. Comparison of molar tooth and hair follicle development between
wild-type and p63 mutant embryos. (A,B) At E11, no
difference could be detected between wild-type and p63-/-
tissues during the initiation of tooth development (arrows). (C-F) At
E12 and E13, dental placodes and tooth buds (arrows) had formed in wild-type
embryos, whereas in the mutant littermates development had arrested at the
stage of thickened dental epithelium (arrows). (G,H) At E16,
wild-type molars had advanced to the bell stage, whereas in p63
mutants the epithelial thickening had degenerated. (I) The first wave
of hair follicles (guard; arrow) had developed to stage 3-4, the placodes of
the second wave awl follicles had appeared in wild-type skin at E16.5 and the
epidermis had increased in thickness. (J) p63-/-
epidermis lacked stratification and hair follicles. sr, stellate reticulum;
dp, dental papilla.
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