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Fig. 5. Expression of Fgfr2b, Fgf8, Bmp7 and
ß-catenin in wild-type and p63 mutant embryos.
(A-D) Fgfr2b transcripts were seen throughout simple
oral epithelium and thickened dental epithelium (E11) and dental placode (E12)
in wild-type embryos, but were absent in the p63 mutant littermate.
(E,F) Fgfr2b transcripts were absent in skin epithelium
of p63 mutants. (G,H) Fgf8 expression was
detected in the area of tooth development both in wild-type and in mutant
embryos prior to morphological tooth formation (E10). (I,J)
Bmp7 transcripts were absent in p63 null oral epithelium.
(K,L) At E14, Bmp7 was expressed throughout surface
ectoderm in a wild-type embryo, whereas expression was completely absent in a
p63 mutant littermate. (M,N) ß-catenin was
intensely expressed both in wild-type and mutant oral epithelium.
(O,P) ß-catenin was downregulated in skin epithelium in the
p63 null embryo. Scale bars: in A, 200 µm for A-L; in M, 500 µm
for M,N; in O, 200 µm for O,P.
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