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Figure 7


Fig. 7. Induction of p63 expression by BMP2, BMP7 and FGF10 in dental epithelium in E13 tooth explants, as analysed by whole-mount in situ hybridisation. Proteins were introduced with beads (A-I) or transfected cells (J) on explants and cultured for 24 hours. Note the endogenous expression of p63 in epithelium in all explants. (A,B) BMP2 and BMP7 induced p63 expression. (C) FGF10 induced p63 expression. (D-J) None of the other signals tested (FGF4, FGF8, Activin, EGF, SHH, TGFß1, WNT6) affected p63 expression. (K,L) Expression of p63 does not require FGFR2b. p63 transcripts were observed throughout ectoderm, in a similar pattern, in both wild-type and Fgfr2b null mutant embryos at E11.





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