spacer gif spacer gif spacer gif spacer gif spacer gif
QUICK SEARCH:   [advanced]


spacer gif
     Home     Help     Feedback     Subscriptions     Archive     Search     Table of Contents    

Right arrow Help viewing high resolution images
Right arrow Return to article
(Downloading may take up to 30 seconds.
If the slide opens in your browser, select File -> Save As to save it.)
Click on image to view larger version.


Figure 3


Fig. 3. Pitx2+/-; Tbx1+/- newborns and embryos exhibit cardiac defects. (A,D,E,F) Histological analysis of Pitx2+/-; Tbx1+/- newborns revealed severe heart defects such as double outlet right ventricle (dorv; arrow), stenosis of the infundibulum (arrowhead) (A), atrial septal defect (asd), ventricular septal defect (vsd) (D), atrio-ventricular valve defects (vad), a common atrio-ventricular junction (cav) (E) and abnormal drainage of pulmonary vein (pv) (F). Pitx2+/- (B,G) and Tbx1+/- (C,H) were normal. Histological analysis of Pitx2+/-; Tbx1+/- E10.5 embryos (J,L) shows grossly malformed hearts compared with wild-type embryos (I,K). ao, aorta; avc, atrio-ventricular canal; la, left atrium; lv, left ventricle; pt, pulmonary trunk; ra, right atrium; rv, right ventricle. Scale bars: 1 mm in A-H; 250 µm in I-L.





Right arrow Return to article