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Figure 4


Fig. 4. In situ hybridization with cardiac markers Tbx3, Tbx2, Nppa and Mhc. Sections from E10.5 wild-type (A,C,E,G) and Pitx2+/-; Tbx1+/- embryos (B,D,F,H). Staining with the Tbx3 (A,B) and Tbx2 (C,D) probes indicates correct molecular patterning in the AVC and inner curvature region. Reduced expression of the chamber marker gene Nppa is found in the Pitx2+/-; Tbx1+/- embryos (E,F), in line with the minor degree of ventricular expansion in the Pitx2+/-; Tbx1+/- embryos, as shown by marker staining for Mhc (G,H). la, left atrium; lv, left ventricle; ra, right atrium; rv, right ventricle. Scale bar: 300 µm in A-H.





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