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Figure 1


Fig. 1. Isl1 marks a subset of progenitors in heart and limb. (A-H) Isl1 lineages in heart. Lineage studies with a new Isl1Cre/+ mouse line give results consistent with those observed utilizing an Isl1-IRES-Cre mouse line (Srinivas et al., 1999; Cai et al., 2003). Excision with the new Isl1Cre/+ occurred more efficiently. Isl1-expressing progenitors contribute to most cells of the outflow tract, right ventricle and atria, and also to some cells in the left ventricle (Cai et al., 203). (I,J) Isl1 lineages in forelimb. Isl1 lineages do not contribute in any significant number to the forelimbs. (K-U) Isl1 lineages in hindlimb. A majority of cells in the hindlimb derive from Isl1-expressing cells. Isl1 cells contribute in an anterior-posterior gradient, with posterior domains deriving almost entirely from Isl1-expressing lineages. Isl1 lineages contribute to hindlimb mesoderm, not ectoderm (S-U). (V-G') Isl1 mRNA expression in lateral plate mesoderm adjacent to and within the limb bud. A comparison of Isl1 mRNA expression to Isl1 lineage results demonstrated that Isl1 mRNA expression is downregulated as hindlimb progenitors migrate into the limb. OFT, outflow tract; RV, right ventricle; LV, left ventricle; A, anterior; P, posterior; Lat, lateral view; Dor, dorsal view; Ven, ventral view.





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