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Fig. 7. Histology and ultrastructure of lung and aorta in Adamts2^-/- mice and wild-type (+/+) littermates. (A) Comparative lung histology from Adamts2^-/- and their wild-type (+/+) littermates. The distal air spaces are much larger in the mutant mice, but there is no inflammatory exudate. (B) Ultrastructure of an alveolar wall, demonstrating comparable basement membranes (arrows) in Adamts2^-/- and wild-type mice. E, erythrocyte. (C) Methylene blue-azure B stain for elastin in Adamts2^-/- and wild-type aortas demonstrates comparable aortic wall thickness and elastin lamellae (arrow). (D) Electron micrograph of collagen fibrils in cross section (in area marked by the asterisk) demonstrates comparable size and shape, and uniformity of fibril diameter. Scale bar: 100 µm in A,C; 500 nm in B,D. (E) Western blot analysis of procollagen III (above) and I (below) processing in mouse lungs. Samples from wild-type and mutant newborn and adult mice are illustrated. (F) Western blot analysis of procollagen III (above) and I (below) processing in the mouse aorta. The various molecular species of collagen are indicated.

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