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First published online March 23, 2006

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Distinct mesenchymal domains in the lung?

During embryonic lung development, interacting signalling molecules made by the developing lung's outer mesothelium, mesenchyme and bronchial epithelium regulate lung growth and morphogenesis. Fibroblast growth factor 9 (FGF9), which is expressed in the mesothelium and epithelium during early lung development, and sonic hedgehog (SHH), which is expressed only in the epithelium, are required for both processes. On p. 1507, David Ornitz and colleagues use Fgf9 loss-of-function and inducible gain-of-function mouse models to show that FGF9 and SHH signalling coordinate lung growth and development by regulating two distinct mesenchymal domains. They report that mesothelium-derived FGF9 signals stimulate proliferation in sub-mesothelial mesenchyme and that epithelium-derived FGF9 signals regulate SHH signalling in a distinct sub-epithelial mesenchyme domain; SHH signalling subsequently regulates cell proliferation and survival, and the expression of mesenchyme-to-epithelial signals. The researchers' report of distinct mesenchymal domains in the developing lung, which respond to different combinations of signalling molecules, is a novel finding that is of relevance to the study of other developing organs.

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Related articles in Development:

FGF9 and SHH signaling coordinate lung growth and development through regulation of distinct mesenchymal domains

Andrew C. White, Jingsong Xu, Yongjun Yin, Craig Smith, Gregory Schmid, and David M. Ornitz
Development 2006 133: 1507-1517. [Abstract] [Full Text]  

This Article Full Text (PDF) Alert me when this article is cited Alert me if a correction is posted Services Email this article to a friend Related articles in Development Similar articles in this journal Alert me to new issues of the journal Download to citation manager Citing Articles Citing Articles via Google Scholar Google Scholar Search for Related Content Social Bookmarking                         What's this?