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Figure 4


Fig. 4. wnt mutants have axon guidance and branching defects. (A) Wild type; PVM process enters VNC and turns anteriorly (ventral view). Arrows indicate PVM process, triangles label PLM process. (B) cwn-1; egl-20; PVM process enters the VNC and turns posteriorly. (C) ALM, PLM, AVM and PVM cell bodies and process trajectories. AVM is on the right-hand side; PVM is on the left-hand side. Boxed areas show regions depicted in fluorescence photomicrographs. (D) Wild type; ALM and AVM processes form branches at their distal ends that make contact within the nerve ring. Arrows indicate AVM nerve ring branch and anterior extension past nerve ring. (E) cwn-1; cwn-2; ALM and AVM fail to form nerve ring branches. AVM process also stops short. Arrow labels termination site of AVM process. Anterior is leftwards; dorsal is towards the top, unless indicated. (F) Phenotypes of AVM and PVM processes in wild type and cwn-1; egl-20 double mutants. Because of overlap with AVM process in anterior body, we were often unable to score the precise end point of the anteriorly directed PVM process; nonetheless, the PVM process was typically shorter in cwn-1; egl-20 double mutants than in wild type.





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